The cause of NVP is yet to be determined. Many researchers believe it happens due to the physical and hormonal changes taking place during early pregnancy.
NVP is extremely common and affects an estimated 80% of pregnant women.
For most women, NVP starts between the 4th and 8th week of pregnancy and ends between the 12th and 16th week. However, NVP can last longer for some women, sometimes up until the end of the pregnancy.
Despite the term ‘morning sickness’, NVP can occur at any time of the day. Its occurrence and severity of NVP varies from woman to woman.
Your baby’s health may be affected if your own health is compromised by NVP. Therefore, it’s important to speak to your doctor about your symptoms.
When taken at an early stage, Doxinate helps alleviate morning sickness and thus improves quality of life for the patient. It also helps prevent the condition from progressing to severe NVP - or hyperemesis gravidarum - which requires hospitalisation to rehydrate the patient.
Doxinate is available in pharmacies across India, as well as the ecommerce platforms Netmeds and 1mg.
Since 1986, the medical community has considered Doxinate the medication of choice for NVP. It has been prescribed to millions of women.
United States Food and Drug Administration (USFDA)
American College of Obstetricians and Gynaecologists (ACOG)
Society of Obstetricians and Gynaecologists of Canada (SOGC)
Motherisk - The Hospital of Sick Children, Toronto, Canada
National Organization for Rare Disorders (NORD)

Doxinate is the most researched medication for use in NVP and has been studied in more than 200,000 women. All studies confirmed Doxinate’s safety and efficacy, no matter how early and for how long it is taken during pregnancy.
Doxinate scored an ‘A’ safety rating in Briggs’ Reference Guide to Fetal and Neonatal Risk.
It does not increase a woman’s baseline risk of having a child with a major malformation.
Doxinate can be used to treat NVP during any trimester of pregnancy. It is shown to be safe during all three trimesters.
A body of research has shown Doxinate to be safe for the baby, no matter how early and for how long it is taken during pregnancy. The dosage should be gradually reduced to avoid a sudden return of NVP symptoms.
Doxinate is specifically indicated for nausea and vomiting during pregnancy, and therefore not indicated for use during lactation. There are no published reports indicating the safety of using it during lactation. Using Doxinate during lactation is considered off-label use.
Doxinate is a combination of doxylamine succinate and pyridoxine. Because of doxylamine succinate’s low molecular weight, it can be passed through breast milk. Its effects on a nursing infant - if any - are unknown, but its sedative and other antihistamine actions are a potential concern. The manufacturer of at least one doxylamine preparation states that doxylamine is not indicated for use during lactation.
Pyridoxine is compatible with breastfeeding because it is present in a low dose in Doxinate tablets. Thus, it presents no risk to nursing infants.
We do not promote the use of Doxinate while breastfeeding. However, if your doctor still chooses to prescribe it, it is important to monitor the baby for signs of sedation, such as sleepiness.
Do not stop taking Doxinate on your own. Always consult your doctor before changing the dosage of your prescription. If your doctor decides to reduce your dosage, it will be gradually reduced to prevent a sudden return of your symptoms.
Doxinate’s delay in action may be prolonged if the dose is taken with food. Instead of taking 4-6 hours, it may take up to 9-11 hours to work optimally.
Drowsiness may last between 4 days to 2 weeks after beginning to take Doxinate. Depending on the patient’s metabolic rate, her body will adjust to the dosage within 2 weeks.
No interaction has been proven between Doxinate and folic acid. It is safe to take both substances at the same time.
Doxinate does not contain tartrazine.
Do not take your Doxinate tablets if the expiry date on the strip indicates that they have expired. Their effectiveness may be altered.
We recommend consulting your doctor for a new prescription.
Even if you were prescribed Doxinate in the past, we recommend consulting your doctor for a new diagnosis. The new prescription’s dosage and schedule will be based on your current symptoms. We do not recommend beginning treatment without a doctor’s supervision.