Doxinate is specifically indicated for nausea and vomiting during pregnancy, and therefore not indicated for use during lactation. There are no published reports indicating the safety of using it during lactation. Using Doxinate during lactation is considered off-label use.
Doxinate is a combination of doxylamine succinate and pyridoxine. Because of doxylamine succinate’s low molecular weight, it can be passed through breast milk. Its effects on a nursing infant - if any - are unknown, but its sedative and other antihistamine actions are a potential concern. The manufacturer of at least one doxylamine preparation states that doxylamine is not indicated for use during lactation.
Pyridoxine is compatible with breastfeeding because it is present in a low dose in Doxinate tablets. Thus, it presents no risk to nursing infants.
We do not promote the use of Doxinate while breastfeeding. However, if your doctor still chooses to prescribe it, it is important to monitor the baby for signs of sedation, such as sleepiness.